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Sword
Technology – Accelerating the Biotechnology Revolution
Sword combines its patent-pending chemistry with Raman Spectroscopy,
an analytical technique used in state-of-the-art testing, such
as explosives detection, chemical and material detection, and art
forgery detection. Combined with Sword’s signal amplifying
chemistry, Raman Spectroscopy can be commercially employed in the
life sciences arena for the first time.
Sword’s Raman-sensitive substrate is converted to a highly
sensitive Raman-active compound in the presence of standard ELISA
detection labels. As such, Sword’s detection system is compatible
with existing ELISA-based diagnostic assays, and does not require
a custom format, antibody system, or other new diagnostic chemistries.
Sword can extend the detection limits of existing diagnostics,
or enable the researcher to easily study newly emerging, low-abundance
biomarkers.
Expanding Our Vision
Instead of observing or measuring a color change or fluorescence
event, Sword’s patent-pending chemistry generates a molecular-level
response in the presence of the target analyte. This breakthrough
detection chemistry delivers a substantial increase in sensitivity
over other colorimetric, fluorescence or chemiluminescence detection
technologies.
Comparably priced to other analytical instrumentation, the Saber
Detection System™ features solid-state components and fiber
optics that provide enduring robustness and reliability under the
most rigorous laboratory conditions.
Sword’s leadership team and investors believe that our technology
will revolutionize the diagnostic arena, with applications that
range from life sciences research, pharmaceutical development,
and clinical diagnostics.
Technology Overview
Many current Immunoassays utilize horseradish peroxidase (HRP),
an enzyme that converts substrates to molecules detectable by a
number of types of detection instruments. The Sword technology
uses existing immunoassays and conjugates with a new type of substrate
that is converted to a Raman-detectable substrate in the presence
of HRP. The advantage of the Sword chemistry is an immensely enhanced
level of sensitivity.
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